Aerospace Engineer turned Deep-Tech & MedTech Entrepreneur
For decades, Dr. Roland Probst has applied aerospace control systems—the precise frameworks used to steer rockets and satellites—to manipulate the microscopic physical and biological world. He designs systems that unify sensing, actuation, and decision-making into a single deterministic loop.
By bridging high-resolution multi-modal optical sensing with deterministic field steering and real-time hardware execution, Dr. Probst has scaled breakthroughs across biotechnology, advanced cell manufacturing, healthcare, image-guided neurostimulation, and defense physical AI powered by proprietary edge control engines.
Core Identity
Unify sensing, actuation, and decision-making into a single deterministic loop—keeping loop latencies and sensor time skew at an absolute minimum.
Solving Deep-Tech Commercial Bottlenecks
Bringing complex physical systems from early laboratory concepts into mission-critical commercial operation requires solving fundamental physics and data bottlenecks at their source.
Hardware-Level Data Chaos
Modern deep-tech projects frequently fail during commercial rollout because engineering teams attempt to fix hardware-level data chaos with expensive, capital-intensive software workarounds.
Unsynchronized multi-sensor streams, latency spikes, and stochastic noise overwhelm downstream cloud and software pipelines, resulting in ballooning compute costs, fragile reliability, and failed clinical or field deployments.
Deterministic Edge Engines & Architectures
I architect deterministic hardware and software-defined edge engines—anchored by proprietary timing and control algorithms—that eliminate bottlenecks directly at the root.
By integrating multi-sensor fusion, edge compute, and ultra-low-latency real-time control, my platforms achieve unprecedented speed, precision, and operational economics across:
Core Areas of Expertise
Comprehensive technical and strategic leadership bridging early-stage venture creation with hardware, firmware, and regulatory execution.
Venture Execution
Building & scaling deep-tech ventures from early seed stages through commercialization. Architecting enterprise business models, IP portfolios, capital allocation, and spin-outs.
Real-Time Systems
High-precision clock synchronization, embedded control architectures, low-latency edge telemetry, dynamic spatial field switching, and deterministic real-time execution.
Technology Transfer
Maturing early-stage lab innovations into compliant, scalable infrastructure under rigorous regulatory and operational frameworks (FDA, CLIA, DoD, DARPA).
Multidisciplinary Teams
Assembling and leading high-performing engineering teams across hardware design, firmware development, optics, physical AI, and software architecture.
Image-Guided Systems & High-Fidelity Bioanalytics
A unified, closed-loop architecture integrating real-time spatial image feedback, deterministic field steering, and parallel optical sensing for high-throughput, non-destructive bioanalytics and therapy.
Image-Guided Dynamic Steering & Precision Clock Sync
Static guidance methods are physically constrained in deep target regions due to energy minimum limitations. Probst pioneered dynamic field inversion—rapidly switching field polarities faster than particle physical re-orientation times to establish a dynamic quasi-static potential trap.
Applicable to deep-tissue magnetic guidance, micro-fluidic positioning, and image-guided neurostimulation, the architecture incorporates high-precision timing synchronization, real-time distributed field mapping, and deterministic safety limits to deliver high targeting accuracy without phase skew.
Parallel Optics Engine & Non-Destructive CQAs
Traditional bioanalytics rely on serial optical scans or software streaming that creates severe data bottlenecks. Probst engineered a high-speed parallel optics edge engine with embedded threshold filtering, achieving high real-time data bandwidth efficiency across multi-channel sensor feeds.
In cell manufacturing, this optical engine powers automated live-cell sorting based on Cell Morphology as a Critical Quality Attribute (CQA). Using spatial lighting and non-destructive vision models, the system evaluates unstained adherent cells in real time without compromising cell viability.
Interactive Deterministic Control Loop Simulation
Demonstrates real-time closed-loop spatial stabilization under physical/fluidic disturbances vs. unconstrained stochastic drift.
Deterministic Real-Time Control for Defense & Physical AI
The control algorithms engineered to stabilize micro-structures under real-time deadlines translate directly into resolving multi-modal latency, sensor skew, and spatial tracking in Counter-UAS tracking, physical AI robotics, and defense networks.
Deterministic Physical AI
Synchronizes multi-modal vision, tactile, spectroscopic, and force streams with active effectors under tight timing precision.
Ultra-Low Readout Latency
Presents modular phase-locking control across multi-node systems for synchronized tracking and counter-measure execution.
Integrated Edge Capabilities
Synchronizes high-speed directional sensing arrays across distributed physical nodes with tight timing coherence via proprietary control protocols.
Reduces network bus bandwidth usage via real-time firmware-level thresholding.
Dual-layer architecture pairing real-time hardware reflexes with agentic reasoning models.
Deep Microelectronics & Advanced Control Systems
Architected modular image-guided control platforms using MPSoCs and FPGAs for high-power, high-frequency electromagnetic pulse delivery in Medical and Counter-UAS applications.
Commercial-to-Defense Technology Transfer
Successfully adapted high-throughput commercial tracking hardware from ultra-fast image-guided cell sorting to solve defense-specific challenges, including Counter-UAS tracking applications.
Proven TRL 2 to TRL 8 Maturation
Led multidisciplinary engineering teams through the full R&D lifecycle, taking early-stage concepts and successfully maturing them into highly regulated, commercialized products.
Agile Technology Scouting & OTAs
Extensive experience co-founding deep-tech startups and structuring venture deals. Uniquely qualified to evaluate external hardware stacks to ensure their technologies are mature, reliable, and ready to integrate.
Commercial Venture Portfolio
Building & scaling deep-tech ventures from early concepts to commercial rollout across MedTech, Bioanalytics, and Physical AI.
ACUITYnano LLC
Translates micro-fluidic control, optical sensing, and magnetic field steering into commercial platforms. Home of proprietary timing and control architectures.
High-Fidelity Bioanalytics Platform
Co-developed next-generation parallel optical bioanalytics engine featuring multi-channel acquisition, real-time data suppression, and low thermal dissipation.
Potomac Deep Tech Foundry
Commercial venture studio building physical AI, real-time edge control, and hardware spin-outs to bridge laboratory innovations to market deployment.
Medisight AI
Architects compliant AI engines analyzing multi-modal imaging dynamics and clinical histories for early disease risk prediction.
Image-Guided Control Engine
Engineered high-precision timing synchronization platform for modular image-guided therapy, neurostimulation, and dynamic safety regulation.
Live-Cell Incubator Sorter
Automated live-cell sorting system evaluating stem cell morphology as a Critical Quality Attribute (CQA) via non-destructive vision.
Intellectual Property & Technical Portfolio
Issued & Pending Patents • Proprietary Control Architectures • Papers in Nano Letters, Lab on a Chip, IEEE CSM (Cover)
| Identifier / Platform | Title & Architectural Innovation Overview | Category | Status / Phase |
|---|---|---|---|
| Proprietary Timing Control Engine | Deterministic Physical AI & Real-Time Clock Sync ArchitectureProprietary nanosecond timing synchronization framework for image-guided systems, Counter-UAS tracking, and robotics. | Physical AI | Proprietary Core |
| Image-Guided Control Engine | Advanced Control Architecture for Image-Guided InterventionsHigh-precision timing synchronization, real-time dynamic switching parameter adjustments, closed-loop field regulation. | Control Platform | Core Platform |
| Parallel Optics Bioanalytics | High-Throughput Parallel Optical Data Acquisition EngineMulti-channel sensor mapping, real-time threshold suppression, low-power board thermal management. | Parallel Optics | Commercial JV |
| Dynamic Magnetic Guidance Patent | Methods and Systems for Magnetic Focusing of Therapeutic Agents to Deep TargetsDynamic inversion field control algorithms bypassing static field limitations for deep target guidance. | Granted Patent | Core IP |
| Micro-Fluidic Precision Control Patent | Arbitrary and Simultaneous Control of Multiple Objects in Micro-Fluidic SystemsMulti-layer microfluidics with dynamic feedback loops for micro-scale electrokinetic position control. | Granted Patent | Core IP |
| IEEE CSM (Cover Article) | Flow Control of Small Objects On-Chip: Manipulating Micro/Nano StructuresTutorial paper on visual-feedback control for microfluidic systems and nanoscale position control. | Journal | Cover Publication |
| Lab on a Chip | Polymer Refractive Index Matching for Diverse Applications in MicroscopyRefractive index-matched polymer enabling diffraction-limited multi-dimensional live-cell imaging. | Journal | Peer-Reviewed |
Multidisciplinary Foundations
From industrial process automation at major chemical Primes to Aerospace Control Ph.D., bridging to image-guided systems and physical AI.
Automation & CS
Industrial process automation at BASF & high-throughput screening entities.
Aerospace Engineering
Dissertation under Prof. Benjamin Shapiro: Applied aerospace control theory to micro/nano electrokinetic traps.
Bioengineering Research
Magnetic particle guidance, lab-to-market translation, and real-time live human cell manipulation.
Deep-Tech Founder & CTO
Building and scaling deep-tech ventures, proprietary edge control engines, and physical AI platforms.
Deploying Mission-Critical Deep-Tech
"Let's connect if you are building, investing in, or deploying mission-critical physical AI and deep-tech platforms."
Available for strategic advisory, venture co-creation, real-time edge architecture consulting, and technology transfer partnerships across FDA, CLIA, and DoD/DARPA domains.